California Institute of Technology · Division of Chemistry & Chemical Engineering
Crystallographers and synthetic chemists. We build electron-microscopy methods to see molecules, and reactive-intermediate chemistry to make them.
Seeing · Electron microscopy, MicroED, cryo-EM
Utilizing transmission electron microscopes, the group determines molecular structures from small natural products to large biomolecules through real-space imaging, electron diffraction, automation, and data processing.
Read moreMaking · Carbocations, main-group catalysis, mechanism
Leveraging data science, computational chemistry, and physical organic tools, the group drives discovery through a reactivity-focused approach guided by reaction mechanisms and transient intermediates.
Read more
Principal Investigator
Professor of Chemistry · Caltech
Hosea earned a B.S. in Chemistry from UC Berkeley and a Ph.D. from Caltech with Brian Stoltz, followed by postdoctoral training at UC Berkeley with F. Dean Toste. He joined UCLA in 2015 and returned to Caltech in 2021 as Professor of Chemistry. His lab develops new tools for small-molecule structural chemistry and reactivity-driven synthesis.
Selected work
Where we are
357 Crellin Laboratory, California Institute of Technology
1200 East California Boulevard, Pasadena, CA 91125
