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Structural Chemistry & Synthesis · Professor of Chemistry
Hosea M. Nelson
B.S. UC Berkeley · Ph.D. Caltech (Stoltz) · Postdoc UC Berkeley (Toste)
hosea@caltech.eduResearch focus
Structural chemistry and reactivity-driven synthesis.
Hosea earned a B.S. in Chemistry from UC Berkeley and a Ph.D. from Caltech with Brian Stoltz, followed by postdoctoral training at UC Berkeley with F. Dean Toste. He joined UCLA in 2015 and returned to Caltech in 2021 as Professor of Chemistry. His lab develops new tools for small-molecule structural chemistry and reactivity-driven synthesis.
Publications
- 2026Discovery and Characterization of a Silicon Aluminum Scandate (SAS) MaterialActa Materialia
- 2025Spatially-Aware Diffraction Mapping Enables Fully Autonomous MicroEDJ. Am. Chem. Soc.
- 2025Combining MicroED and Native Mass Spectrometry for Structural Discovery of Enzyme-Small Molecule ComplexesProc. Natl. Acad. Sci. U.S.A.
- 2025Microcrystal Electron Diffraction-Guided Discovery of Fungal MetabolitesJ. Am. Chem. Soc.
- 2025Genome Mining of Fungal Aza-Polycyclic Natural Products Derived from Arginine-Containing CyclodipeptidesJ. Nat. Prod.
- 2024Carbon-Carbon Bond Forming Reactions of Vinyl Cations: A Personal PerspectiveEur. J. Org. Chem.
- 2024High-Silica, Enantiomerically Enriched STW-Type Molecular SieveChem. Mater.
- 2024Main Group-Catalyzed Cationic Claisen Rearrangements via Vinyl CarbocationsOrg. Lett.
- 2024Accessing Medium-Sized Rings via Vinyl Carbocation IntermediatesOrg. Lett.
- 2024High-throughput Identification of Crystalline Natural Products from Crude Extracts Enabled by Microarray Technology and MicroEDACS Cent. Sci.
- 2023α-Vinylation of Ester Equivalents via Main Group Catalysis for the Construction of Quaternary CentersOrg. Lett.
- 2022Catalytic asymmetric C–H insertion reactions of vinyl carbocationsScience
- 2022Electrochemical Fluorination of Vinyl Boronates Through Donor-Stabilized Vinyl Carbocation IntermediatesAngew. Chem. Int. Ed.
- 2019Nonclassical Applications of closo-Carborane Anions: From Main Group Chemistry and Catalysis to Energy StorageChem. Rev.
- 2019Vinyl Carbocations Generated under Basic Conditions and Their Intramolecular C–H Insertion ReactionsJ. Am. Chem. Soc.
- 2018The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure DeterminationACS Cent. Sci.
- 2014Catalytic Intermolecular C–H Silylation of Arenes by High-Valent Iron ComplexesScience
MicroED, 0.9 Å
Drimane-type metabolite
A trans-fused bicyclic terpenoid with a γ-lactone. The absolute configuration came from a single microcrystal, invisible to the naked eye.
C 15O 3228.2 g/mol